Answer
Taking amitriptyline hydrochloride with tramadol increases the risk of seizures and serotonin syndrome and can inhibit tramadol's conversion to its active metabolite, increasing tramadol concentrations and potentially causing opioid toxicity.
Sources for this answer
- Amitriptyline Hydrochloride 50mg/5ml Oral SolutionRosemont Pharmaceuticals Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated
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