Answer
Combining remifentanil hydrochloride with benzodiazepines or related sedatives may cause sedation, respiratory depression, coma and death; reserve co-prescribing for patients without alternative options, use the lowest effective dose for the shortest possible duration, monitor closely for sedation and respiratory depression, and inform patients and caregivers of these symptoms.
Sources for this answer
- Remifentanil 1mg Powder for Concentrate for Solution for Injection or InfusionWockhardt UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 6Document updated
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