zonisamide · Medicine question

What risk may be increased when zonisamide is taken with valproate?

Name: What risk may be increased when zonisamide is taken with valproate?
Published: 2026-11-08T02:05:54.959Z

iatroX medicinesPublished 8 November 2026

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Taking zonisamide with valproate may increase the risk of hyperammonaemia, which has been reported with or without encephalopathy during zonisamide treatment.

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Zonegran 25 mg Hard CapsulesADVANZ Pharma · emc · SmPC §4.4 Special warnings and precautions for use · Version 34Document updated 16 February 2024

Sources checked 8 November 2026

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