Answer
Combining Lantus (insulin glargine) with pioglitazone carries a risk of heart failure, especially in patients with heart-failure risk factors, requiring monitoring for heart failure, weight gain and oedema and discontinuation of pioglitazone if cardiac symptoms deteriorate.
Sources for this answer
- Lantus 100 units/ml solution for injection in a vialSANOFI · emc · SmPC §4.4 Special warnings and precautions for use · Version 12Document updated
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