insulin degludec · Medicine question

What risk has been reported when pioglitazone is used with insulin such as insulin degludec (Tresiba)?

Name: What risk has been reported when pioglitazone is used with insulin such as insulin degludec (Tresiba)?
Published: 2026-11-08T01:52:20.386Z

iatroX medicinesPublished 8 November 2026

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Heart failure has been reported when pioglitazone is combined with insulin, a risk relevant to insulin degludec (Tresiba), especially in patients with risk factors for heart failure.

Sources for this answer

Tresiba 100 units/mL PenfillNovo Nordisk Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 2Document updated 6 November 2025

Sources checked 8 November 2026

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