pegfilgrastim · Medicine question

What modification of G-CSF gives pegfilgrastim its sustained duration of action?

Name: What modification of G-CSF gives pegfilgrastim its sustained duration of action?
Published: 2026-11-08T14:29:33.626Z

iatroX medicinesPublished 8 November 2026

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Pegfilgrastim is recombinant human G-CSF covalently conjugated to a single 20 kd polyethylene glycol (PEG) molecule, giving sustained action through decreased renal clearance.

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Pelmeg 6 mg solution for injection in pre-filled syringeNapp Pharmaceuticals Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 8Document updated 3 March 2025

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