Answer
Tioguanine is associated with vascular endothelial liver damage, hepatic veno-occlusive disease, portal hypertension, hepatoportal sclerosis, nodular regenerative hyperplasia, peliosis hepatis and periportal fibrosis; maintenance or similar long-term continuous treatment is not recommended because of the high liver-toxicity risk.
Sources for this answer
- Tioguanine 40 mg TabletsAspen · emc · SmPC §4.4 Special warnings and precautions for use · Version 9Document updated
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