Answer
Imlifidase is a cysteine protease derived from Streptococcus pyogenes that cleaves heavy chains of all human IgG subclasses, but no other immunoglobulins, eliminating Fc-dependent effector functions, including complement-dependent and antibody-dependent cell-mediated cytotoxicity, and reducing donor-specific antibodies to enable transplantation.
Sources for this answer
- Idefirix 11 mg powder for concentrate for solution for infusionHansa Biopharma AB · emc · SmPC §5.1 Pharmacodynamic properties · Version 7Document updated
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