Answer
The mean elimination half-life of cobimetinib after oral dosing is 43.6 hours (range: 23.1–69.6 hours), and complete removal from systemic circulation may take up to 2 weeks after treatment cessation.
Sources for this answer
- Cotellic 20 mg film-coated tabletsRoche Products Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 14Document updated
Sources checked