Answer
Lidocaine’s adult elimination half-life is 1.5–2 hours, potentially increasing to 4–12 hours in severe heart failure or 4.5–6 hours in chronic liver disease, approximately doubling in severe renal insufficiency, and potentially prolonged in elderly patients or those with impaired liver perfusion.
Sources for this answer
- Lidocaine 10 mg/ml (1 % w/v) solution for injection in pre-filled syringeAguettant Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 4Document updated
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