Answer
Clindamycin phosphate, inactive in vitro, is rapidly hydrolysed in vivo to active clindamycin, which binds the bacterial ribosome’s 50S subunit and inhibits protein synthesis, producing predominantly bacteriostatic activity, although high concentrations may be slowly bactericidal against sensitive strains.
Sources for this answer
- Dalacin C Phosphate Sterile Solution, Clindamycin 150 mg/ml Solution for InjectionPfizer Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 25Document updated
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