Sertraline · Medicine question

What is sertraline's mechanism of action?

iatroX medicinesPublished 8 November 2026

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Sertraline potently and selectively inhibits neuronal serotonin (5-HT) uptake in vitro, potentiating serotonin’s effects in animals, with only very weak effects on neuronal norepinephrine and dopamine reuptake.

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Lustral 50 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 46Document updated 2 February 2026

Sources checked 8 November 2026

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