tapentadol hydrochloride · Medicine question

What is known about the effects of Palexia SR (tapentadol hydrochloride) on fertility in humans and rats?

Name: What is known about the effects of Palexia SR (tapentadol hydrochloride) on fertility in humans and rats?
Published: 2026-11-08T14:29:31.462Z

iatroX medicinesPublished 8 November 2026

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No human data on Palexia SR (tapentadol hydrochloride) and fertility are available; a fertility and early embryonic development study found no effects on reproductive parameters in male or female rats.

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Palexia SR 250 mg prolonged-release tabletsGrunenthal Ltd · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 10Document updated 13 January 2026

Sources checked 8 November 2026

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