Duloxetine · Medicine question

What is duloxetine's mechanism of action?

iatroX medicinesPublished 8 November 2026

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Duloxetine inhibits serotonin and noradrenaline reuptake and weakly inhibits dopamine reuptake, with no significant affinity for histaminergic, dopaminergic, cholinergic or adrenergic receptors.

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Duloxetine Dr. Reddy's 30 mg Gastro-Resistant Capsules, HardDr. Reddy's Laboratories (UK) Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated 22 August 2024

Sources checked 8 November 2026

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