Answer
Combining COSOPT with CYP2D6 inhibitors such as fluoxetine, paroxetine or quinidine can potentiate systemic beta-blockade from its timolol component, with reported effects including decreased heart rate and depression.
Sources for this answer
- COSOPT 20 mg/ml + 5 mg/ml, eye drops, solutionSanten UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated
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