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Medicines Co-amoxiclavQuestion & answer

Co-amoxiclav · Medicine question

What interaction can occur between co-amoxiclav and methotrexate?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Co-amoxiclav may reduce methotrexate excretion, potentially increasing methotrexate toxicity.

Sources for this answer

Augmentin 125/31 SuspensionGlaxoSmithKline UK · emc · SmPC §4.5 Interaction with other medicinal products · Version 20Document updated 13 March 2026

Sources checked 8 November 2026

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Co-amoxiclav

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