Answer
In healthy adults given warfarin 25 mg once, tigecycline reduced R-/S-warfarin clearance by 40%/23% and increased respective AUCs by 68%/29%, without evidence suggesting significant INR changes; coagulation tests require close monitoring because tigecycline may prolong PT and aPTT.
Sources for this answer
- Tygacil 50mg powder for solution for infusion / Tigecycline 50 mg powder for solution for infusionPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 42Document updated
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