Answer
Heart failure has been reported with pioglitazone and insulin, including the warning for Apidra (insulin glulisine), especially in patients with risk factors; monitor for heart failure, weight gain and oedema, and discontinue pioglitazone if cardiac symptoms deteriorate.
Sources for this answer
- Apidra 100 Units/ml solution for injection in a vialSANOFI · emc · SmPC §4.4 Special warnings and precautions for use · Version 3Document updated
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