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Medicines panitumumabQuestion & answer

panitumumab · Medicine question

What happens to the EGFR receptor after panitumumab binds to it?

iatroX medicinesPublished 8 November 2026

The answer

Answer

After panitumumab binds to EGFR, the receptor is internalised, and receptor autophosphorylation induced by all known EGFR ligands is inhibited.

Sources for this answer

Vectibix 20 mg/mL concentrate for solution for infusionAmgen Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 27Document updated 23 July 2025

Sources checked 8 November 2026

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panitumumab

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