netupitant + palonosetron hydrochloride · Medicine question

What fertility-related findings have been observed in animal studies of the active ingredients in Akynzeo?

Name: What fertility-related findings have been observed in animal studies of the active ingredients in Akynzeo?
Published: 2026-11-08T14:29:38.589Z

iatroX medicinesPublished 8 November 2026

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For Akynzeo’s active ingredients, animal studies found no effect of netupitant on fertility, while degeneration of seminiferous epithelium was observed in a rat study of palonosetron.

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Akynzeo 300mg/0.5mg hard capsulesChugai Pharma UK Limited · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 8Document updated 26 June 2026

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