vutrisiran sodium · Medicine question

What enables vutrisiran sodium (Amvuttra) to be delivered to liver cells?

Name: What enables vutrisiran sodium (Amvuttra) to be delivered to liver cells?
Published: 2026-11-08T14:37:00.413Z

iatroX medicinesPublished 8 November 2026

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Vutrisiran in Amvuttra is covalently linked to a ligand containing three N-acetylgalactosamine (GalNAc) residues, enabling delivery to liver cells (hepatocytes).

Sources for this answer

Amvuttra 25 mg solution for injection in pre-filled syringeAlnylam UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 5Document updated 16 July 2025

Sources checked 8 November 2026

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