Answer
At high doses, the lidocaine component of lidocaine with adrenaline has a quinidine-like action on the myocardium, causing cardiac depression.
Sources for this answer
- Lidocaine 10 mg/ml (1% w/v) with Adrenaline (Epinephrine) 1:200 000 solution for injectionAguettant Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated
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