Answer
Berotralstat dihydrochloride weakly inhibits P-gp and increased digoxin peak concentration (Cmax) by 58% and total exposure (AUC) by 48%, so digoxin dose adjustment may be required according to its prescribing information.
Sources for this answer
- Orladeyo 150mg capsuleBioCryst UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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