What do Tecfidera pregnancy registry data indicate about malformations and foetal or neonatal toxicity following early pregnancy exposure to dimethyl fumarate?

Tecfidera registry data from 289 pregnancy outcomes indicate no malformative or foetal/neonatal toxicity versus the general population after early dimethyl fumarate exposure (median 4.6 gestational weeks; limited exposure after week six), but risks with longer exposure or exposure later in pregnancy are unknown.