What condition should be considered if severe, persistent diarrhoea occurs during cefadroxil monohydrate treatment?

Severe, persistent diarrhoea during cefadroxil monohydrate treatment should prompt consideration of antibiotic-associated pseudomembranous colitis; in that case, cefadroxil must be discontinued immediately, suitable therapy started, and antiperistaltics avoided because they are contraindicated.