Answer
Decreased bone mineral density, osteopenia, osteoporosis and fractures have been reported with long-term valproic acid (valproate) treatment; the mechanism affecting bone metabolism has not been identified.
Sources for this answer
- Convulex 150 mg CapsulesG.L Pharma UK Limited · emc · SmPC §4.8 Undesirable effects · Version 8Document updated
Sources checked