What benefit–risk assessment is required before using methylprednisolone sodium succinate during breastfeeding?

Methylprednisolone sodium succinate (Solu-Medrone 40 mg for injection) should be used during breastfeeding only after careful assessment of the benefit–risk ratio to the mother and infant; corticosteroids enter breast milk in small amounts, although methylprednisolone doses up to 40 mg daily are unlikely to cause systemic effects in the infant.