Answer
The most serious adverse reactions associated with Holoclar implantation are corneal perforation and ulcerative keratitis, which may occur within three months and relate to poor corneal stem-cell engraftment, and vasovagal syncope occurring on the first day after surgery due to eye pain.
Sources for this answer
- Holoclar 79,000 - 316,000 cells/cm2 living tissue equivalentHolostem s.r.l · emc · SmPC §4.8 Undesirable effects · Version 4Document updated
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