Answer
Eravacycline is metabolised primarily through CYP3A4- and FMO-mediated oxidation of its pyrrolidine ring to TP-6208 and chemical epimerisation at C-4 to TP-498.
Sources for this answer
- Xerava 100 mg powder for concentrate for solution for infusionPAION UK Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 3Document updated
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