tenecteplase · Medicine question

What are the initial and terminal plasma half-lives of tenecteplase after an intravenous bolus in patients with acute myocardial infarction?

iatroX medicinesPublished 8 November 2026

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After a single intravenous bolus in patients with acute myocardial infarction, tenecteplase has an initial, dominant plasma half-life of 24 ± 5.5 minutes (mean ± SD) and a terminal half-life of 129 ± 87 minutes.

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Metalyse 10,000 unitsBoehringer Ingelheim Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 11Document updated 16 September 2026

Sources checked 8 November 2026

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