Answer
In adults taking Malarone, the elimination half-lives are approximately 2–3 days for atovaquone and 12–15 hours for proguanil; in severe renal impairment, proguanil’s half-life is prolonged to 39 hours, creating potential for accumulation with repeated dosing.
Sources for this answer
- MalaroneGlaxoSmithKline UK · emc · SmPC §5.2 Pharmacokinetic properties · Version 29Document updated
Sources checked