Answer
For empagliflozin + metformin (Synjardy), apparent terminal elimination half-lives are approximately 12.4 hours for empagliflozin (population pharmacokinetic estimate) and 6.5 hours for metformin following an oral dose, with metformin’s half-life prolonged in renal impairment.
Sources for this answer
- Synjardy film coated tabletsBoehringer Ingelheim Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 31Document updated
Sources checked