What adverse effect may be more likely when bupivacaine is used with dapsone?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Concurrent use of bupivacaine with dapsone may increase the risk of methaemoglobinaemia.

EXPAREL 133mgPacira Biosciences · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated 12 January 2023

Sources checked 8 November 2026

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bupivacaine · Medicine question

iatroX medicinesPublished 8 November 2026

The answer

Concurrent use of bupivacaine with dapsone may increase the risk of methaemoglobinaemia.

EXPAREL 133mgPacira Biosciences · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated 12 January 2023

Sources checked 8 November 2026

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