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Question preview · MRCPCH TAS

A 3-day-old neonate requires intravenous gentamicin for suspected sepsis. Which pharmacokinetic property of gentamicin is most important when determining the dosing interval in this patient?

  1. A. High volume of distribution
  2. B. Low protein binding
  3. C. Concentration-dependent killing
  4. D. Hepatic first-pass metabolism
  5. E. Renal tubular secretion

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