dupilumab · Medicine question

Through which receptor complexes does dupilumab inhibit IL-4 and IL-13 signalling?

Name: Through which receptor complexes does dupilumab inhibit IL-4 and IL-13 signalling?
Published: 2026-11-08T13:45:35.470Z

iatroX medicinesPublished 8 November 2026

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Dupilumab inhibits IL-4 signalling via the Type I receptor complex (IL-4Rα/γc) and both IL-4 and IL-13 signalling through the Type II receptor complex (IL-4Rα/IL-13Rα).

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Dupixent 300 mg solution for injection in pre-filled syringeSANOFI · emc · SmPC §5.1 Pharmacodynamic properties · Version 27Document updated 26 November 2025

Sources checked 8 November 2026

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