First-line treatment options for patients diagnosed with delusional disorder include the use of oral antipsychotic medication combined with psychological interventions such as individual cognitive behavioural therapy (CBT) and family intervention.
Antipsychotic medication should be initiated in consultation with a psychiatrist, especially if the presentation is a first episode of sustained psychotic symptoms, and treatment choice should consider clinical response and side effects from previous medications.
Psychological interventions should be delivered by trained professionals with appropriate supervision, and family intervention is recommended particularly for those in close contact with the patient.
Early intervention services should provide a comprehensive range of pharmacological, psychological, social, occupational, and educational interventions tailored to the individual.