Which antibiotics are recommended as first-line treatment for uncomplicated dacryocystitis in adults?

First-line antibiotics for uncomplicated dacryocystitis in adults are not explicitly detailed in the provided UK guidelines. However, based on common clinical practice and the typical causative organisms (usually Staphylococcus aureus and Streptococcus species), first-line treatment often includes oral antibiotics effective against these bacteria, such as flucloxacillin or co-amoxiclav.

Flucloxacillin is commonly used for skin and soft tissue infections caused by Staphylococcus aureus and is recommended in related infections such as diabetic foot infections ².

Co-amoxiclav is also frequently used for infections involving mixed flora and is recommended as a first-choice oral antibiotic in other soft tissue infections ¹,².

In cases of penicillin allergy, alternatives such as cephalexin or clindamycin may be considered, although these are not specifically cited for dacryocystitis in the provided guidelines.