What immediate steps should I take if I suspect a transfusion reaction in my patient?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed

Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

If you suspect a transfusion reaction in your patient, the immediate steps involve:

Monitoring the patient's condition and vital signs: This should be done before, during, and after blood transfusions to detect acute reactions that may require immediate investigation and treatment .
Ensuring a suitable environment with trained staff: Patients who are having or have had a blood transfusion should be observed in an environment where staff are able to monitor and manage acute reactions .

Key References

NG24 - Blood transfusion