What is the recommended antibiotic regimen for the treatment of SBP in patients with cirrhosis?

For the treatment of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis, the recommended initial antibiotic regimen typically involves a third-generation cephalosporin ². Cefotaxime is a commonly used empirical antibiotic for community-acquired SBP (Fiore et al., 2018; Maraolo et al., 2018). Other third-generation cephalosporins, such as ceftriaxone, are also considered effective options for empirical treatment (Maraolo et al., 2018). These antibiotics are generally recommended due to their broad-spectrum activity against common causative organisms of SBP (Fiore et al., 2018).