Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX
For the treatment of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis, the recommended initial antibiotic regimen typically involves a third-generation cephalosporin NICE CKS. Cefotaxime is a commonly used empirical antibiotic for community-acquired SBP Fiore et al. 2018Maraolo et al. 2018. Other third-generation cephalosporins, such as ceftriaxone, are also considered effective options for empirical treatment Maraolo et al. 2018. These antibiotics are generally recommended due to their broad-spectrum activity against common causative organisms of SBP Fiore et al. 2018.
Key References
- NG50 - Cirrhosis in over 16s: assessment and management
- CKS - Cirrhosis
- CKS - Olecranon bursitis
- CKS - Pelvic inflammatory disease
- NG78 - Cystic fibrosis: diagnosis and management
- NG147 - Diverticular disease: diagnosis and management
- (Fiore et al., 2018): Are third-generation cephalosporins still the empirical antibiotic treatment of community-acquired spontaneous bacterial peritonitis? A systematic review and meta-analysis.
- (Maraolo et al., 2018): Current and emerging pharmacotherapy for the treatment of bacterial peritonitis.