What are the recommended first-line treatment options for newly diagnosed multiple myeloma in adults?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

The recommended first-line treatment options for adults with newly diagnosed multiple myeloma include bortezomib in combination with dexamethasone, or with dexamethasone and thalidomide, for those eligible for high-dose chemotherapy with stem cell transplantation .

For patients in whom high-dose chemotherapy is considered inappropriate, thalidomide in combination with an alkylating agent and a corticosteroid is recommended as an option .

Related Knowledge Topics

Educational content only. Always verify information and use clinical judgement.