How should I initiate empirical antibiotic therapy for a patient with suspected neutropenic sepsis?

Offer beta lactam monotherapy with piperacillin/tazobactam as initial empiric antibiotic therapy to patients with suspected neutropenic sepsis who need intravenous treatment, unless there are patient-specific or local microbiological contraindications ¹.

Do not offer an aminoglycoside, either as monotherapy or in dual therapy, for the initial empiric treatment of suspected neutropenic sepsis unless there are patient-specific or local microbiological indications ¹.

Do not offer empiric glycopeptide antibiotics to patients with suspected neutropenic sepsis who have central venous access devices unless there are patient-specific or local microbiological indications ¹.

Do not remove central venous access devices as part of the initial empiric management of suspected neutropenic sepsis ¹.