Dr Kola Tytler MBBS CertHE MBA MSt MRCGPClinical Lead • iatroX
Offer a choice of amitriptyline, duloxetine, gabapentin, or pregabalin as the first-line pharmacological treatments for neuropathic pain in adults NICE CKS.
What are the recommended first-line pharmacological treatments for neuropathic pain in adults?
Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP.
Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed