What are the recommended first-line treatments for vulvovaginal candidiasis in non-pregnant women?

Recommended first-line treatments for vulvovaginal candidiasis in non-pregnant women:

• Oral fluconazole 150 mg as a single dose is advised first-line for acute vulvovaginal candidiasis.
• If oral therapy is contraindicated or not tolerated, clotrimazole 500 mg intravaginal pessary as a single dose is recommended as an alternative first-line treatment.
• For women with vulval symptoms, consider adding topical clotrimazole cream (1% or 2%) applied 2–3 times daily alongside oral or intravaginal antifungal treatment.
• In cases of severe infection, a repeat dose of oral fluconazole 150 mg on day 4 is advised.

These treatments are suitable for women aged 16 years and older and should be selected based on individual factors such as co-morbidities, personal preference, and drug contraindications.