Which first-line treatments are recommended for managing hyperemesis gravidarum in primary care settings?

The recommended first-line treatments for managing hyperemesis gravidarum in primary care are oral cyclizine or promethazine (antihistamines), prochlorperazine or chlorpromazine (phenothiazines), or the combination drug doxylamine/pyridoxine (Xonvea®), depending on patient preference and local guidelines NICE CKS.