What are the potential complications of GPA that I should be aware of when managing patients in primary care?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

When managing patients with granulomatosis with polyangiitis (GPA) in primary care, it is important to be aware that GPA is a form of vasculitis, previously known as Wegener granulomatosis . A significant potential complication to be aware of is lung involvement, as this is a common feature in ANCA-associated vasculitis, which includes GPA .

Educational content only. Always verify information and use clinical judgement.