What are the key clinical features that suggest a diagnosis of amyloidosis in a patient presenting with unexplained organ dysfunction?

When a patient presents with unexplained organ dysfunction, key clinical features that may suggest a diagnosis of amyloidosis often depend on the organs affected. For instance, in cases of gastrointestinal amyloidosis, patients may exhibit symptoms such as malabsorption, chronic diarrhoea, constipation, or signs consistent with pseudo-obstruction Petre et al. 2008. Additionally, hepatomegaly can be a clinical feature observed in gastrointestinal amyloidosis Petre et al. 2008. While specific clinical features of amyloidosis are not explicitly detailed within guidelines for suspected cancer, the presence of unexplained organ dysfunction itself is a significant indicator that warrants thorough investigation and appropriate referral, aligning with the principles for identifying serious underlying conditions NICE NG12.