What are the recommended routine screening tests during antenatal care

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

During routine antenatal care for healthy pregnant women, the recommended screening tests include:

Measurement of height and weight to calculate body mass index (BMI) at the booking appointment to assess risk factors such as venous thromboembolism and pre-eclampsia ,,.
Blood tests at the booking appointment to check full blood count, blood group, and rhesus D status ,,.
Screening for infectious diseases including HIV, syphilis, and hepatitis B as part of the NHS infectious diseases in pregnancy screening programme ,,.
Screening for sickle cell and thalassaemia according to the NHS sickle cell and thalassaemia screening programme ,,.
Fetal anomaly screening through ultrasound scans offered between 11+2 and 14+1 weeks and again between 18+0 and 20+6 weeks to detect fetal anomalies and determine gestational age and placental location .
Repeat blood tests at 28 weeks to check full blood count, blood group, antibodies, and offer anti-D prophylaxis to rhesus-negative women .
Urine dipstick testing for proteinuria and blood pressure measurement at every routine face-to-face antenatal appointment to monitor for hypertension and pre-eclampsia ,,.
Assessment of risk factors for gestational diabetes at booking, with oral glucose tolerance testing offered between 24+0 and 28+0 weeks if risk factors are present, especially in women with BMI over 30 kg/m2 ,,.
Assessment of risk factors for venous thromboembolism at booking and after any significant health event during pregnancy, with referral to obstetrics if at risk ,,.
Screening and discussion of mental health conditions in pregnancy ,.

Women should be informed about the screening programmes and have the right to accept or decline any part of the screening offered ,,.

What are the recommended routine screening tests during antenatal care for healthy pregnant women?