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What are the recommended first-line treatments for managing osteoarthritis in primary care?

Answer

Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 14 August 2025

Offer individualized management plans based on severity, affected joints, physical function, and comorbidities 1.

Advise on self-care strategies, including weight management, appropriate footwear, and sources of information and support 1.

Recommend therapeutic exercise, including local muscle strengthening and general aerobic fitness, with consideration of supervised sessions 1, 3.

Advise that joint pain may increase initially when starting therapeutic exercise, but regular exercise will be beneficial long-term 1, 3.

Use simple analgesia, such as over-the-counter topical NSAIDs like ibuprofen 5% gel applied up to three times daily for knee OA, or consider topical NSAIDs for other joints 1.

If topical NSAIDs are ineffective or unsuitable, consider oral NSAIDs, using the lowest effective dose for the shortest possible time, with caution regarding contraindications and risks 1, 3.

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This content was generated by iatroX. Always verify information and use clinical judgment.