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What are the recommended first-line pharmacological treatments for managing Type 2 Diabetes in adults?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 14 August 2025
The recommended first-line pharmacological treatment for managing Type 2 Diabetes in adults is standard-release metformin. 1
If metformin is contraindicated or not tolerated, consider an SGLT2 inhibitor with proven cardiovascular benefit, especially in patients with cardiovascular disease or high risk of it. 1
When starting dual therapy with metformin and an SGLT2 inhibitor, introduce the drugs sequentially, starting with metformin and checking tolerability. 1
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