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iatroX Rounds #18

Saturday, 11 July 2026·Respiratory medicinemoderate

The clues

  1. 1

    A 58-year-old woman presents to her GP with a persistent cough and several months of general lethargy.

  2. 2

    She describes the cough as being most troublesome in the mornings when she expectorates significant amounts of thick, yellow-green sputum.

  3. 3

    She has a history of severe pneumonia as a child and has noticed occasional streaks of blood in her phlegm over the last year.

  4. 4

    Physical examination reveals finger clubbing and coarse inspiratory crackles at the lung bases that partially clear after coughing.

  5. 5

    Routine sputum microbiology repeatedly identifies the presence of Haemophilus influenzae and occasionally Pseudomonas aeruginosa.

  6. 6

    High-resolution CT imaging shows dilated, thick-walled airways with a lack of tapering, and a bronchial-to-arterial ratio greater than one.

the diagnosis
Bronchiectasis

Bronchiectasis is a chronic condition characterized by permanent, abnormal dilatation of the bronchi due to a cycle of inflammation and infection. It presents with a chronic productive cough, copious purulent sputum, and recurrent chest infections.

  • Daily productive cough with large volumes of purulent sputum
  • Coarse inspiratory crackles that clear or shift with coughing
  • Association with previous severe respiratory infections such as pertussis or measles
  • Finger clubbing and haemoptysis are common clinical features
pearl. The signet ring sign on HRCT, where the internal diameter of the bronchus is wider than the adjacent pulmonary artery, is the hallmark diagnostic finding.

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